Molecular Analysis of Mammalian Timeless
نویسندگان
چکیده
منابع مشابه
Molecular Analysis of Mammalian Timeless
We cloned the mouse cDNA of a mammalian homolog of the Drosophila timeless (tim) gene and designated it mTim. The mTim protein shows five homologous regions with Drosophila TIM. mTim is weakly expressed in the suprachiasmatic nuclei (SCN) but exhibits robust expression in the hypophyseal pars tuberalis (PT). mTim RNA levels do not oscillate in the SCN nor are they acutely altered by light expos...
متن کاملRequirement of mammalian Timeless for circadian rhythmicity.
Despite a central circadian role in Drosophila for the transcriptional regulator Timeless (dTim), the relevance of mammalian Timeless (mTim) remains equivocal. Conditional knockdown of mTim protein expression in the rat suprachiasmatic nucleus (SCN) disrupted SCN neuronal activity rhythms, and altered levels of known core clock elements. Full-length mTim protein (mTIM-fl) exhibited a 24-hour os...
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We report the identification, characterization, and cloning of a novel Drosophila circadian rhythm gene, dClock. The mutant, initially called Jrk, manifests dominant effects: heterozygous flies have a period alteration and half are arrhythmic, while homozygous flies are uniformly arrhythmic. Furthermore, these flies express low levels of the two clock proteins, PERIOD (PER) and TIMELESS (TIM), ...
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Multiple structural, biochemical and in vivo studies have solidified the role that histone acetyltransferases (HATs) play in regulation of the p53 pathway. 1 HATs are known to modulate p53 functions in many ways, from regulating its stability to promoting acetyla-tion-dependent interactions with DnA as well as various co-factors and chromatin modi-fiers. 1 Of these, p300, CBP, PCAF and Tip60 ar...
متن کاملTimeless Games
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ژورنال
عنوان ژورنال: Neuron
سال: 1998
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80628-5